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Figure203

Alterations in the human insulin chains to produce Levemir (Detemir) and Lantus (Glargine)--long-acting analog insulins.

These insulins are analogs, created artificially rather than extracting them from animals or duplicating human insulin. Although they function like insulin, they have specific molecular differences designed to alter their action profile.

Insulin analogs (or analogues) are chemically-synthesized molecules that function similarly to insulin, but have alterations which change their speed of absorption or other properties. The basic "building block" of all analog insulins is the human insulin molecule, as it is to this where the modifications for speed or length are made.

CP120

Alterations in the human insulin chains to produce Apidra (Glulisine), Novolog/NovoRapid (Aspart), and Humalog (Lispro)--all rapid-acting analog insulins.




We in the Pet Diabetes world are most familiar with Lantus and Levemir as ultra-slow acting insulin analogs, but much research also goes into ultra-fast-acting analogs such as Humalog, Apidra, and Novolog/NovoRapid.

When pets and people are experiencing diabetic emergencies such as DKA the rapid-acting Novolog, NovoRapid (aspart), Humalog (lispro) or (glulisine) Apidra may be used to bring the blood glucose levels down. Dr. Nelson of University of California-Davis said in his lecture at the Ohio State Endocrinology Symposium in 2006 that if the short-acting analog insulins have any role in feline and canine diabetes, it is not yet determined. [1][2]

Many people with diabetes opt for one of these three for their bolus insulin, whether they use Lantus or Levemir for their basal or not. I16

Analog InsulinsEdit

Analog insulins: amino acid sequenceEdit

Analog insulins: pharmacokineticsEdit


These are human activity profiles.

ReferencesEdit

  1. Nelson, Richard (2006). Selecting an Insulin for Treating Diabetes Mellitus in Dogs & Cats-page 39. OSU Endocrinology Symposium.
  2. Abrams-Ogg, Anthony (2007). Evaluating Insulin Products for Companion Animals. ACVIM.
  3. 3.0 3.1 Guide to Insulin Preparations. Pharmacy Times.
  4. 4.0 4.1 Insulin Pharmacology. Endotext.org.
  5. NetDoctor.uk Hypurin Protamine Zinc. NetDoctor UK.

More InformationEdit

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