Betasint Bovine NPH
NPH/isophane by Beta Laboratorios
U40, U80, U100 isophane
Action in dogs:
  • onset within 2h,
  • peak 6-12h,
  • duration 18-14h
Line: Betasint
Also known as: Beef NPH, beef isophane
Similar to: Hypurin Bovine Isophane, Iletin NPH
Use and Handling:
Shelf Life: 36 months Type: cloudy
When Opened: 28 days room temp.
In Pen: 28 days room temp.
Notes: Protect from light and heat
Do Not Freeze, Re-suspend
Do not use if product does not re-suspend

Cartridges in use are not to be refrigerated
Do not use intravenously [1]
May be used intramuscularly, which means onset, peak and duration times are shorter.
Store between 2-8C,
May be mixed with Bovine Neutral


Betasint logo. Bovine insulin was successfully extracted in January 1987-porcine followed in June of the same year.

This is an intermediate-acting beef isophane insulin. Betasint Bovine NPH [2][3] is comparable to Hypurin Bovine Isophane. [4][5][6]

A comparable product, formerly made by Eli Lilly was all-beef Iletin I NPH.

Specifications of NPH/isophane insulinEdit

British National Formulary [7] defines this type as: A sterile suspension bovine or porcine or of human insulin in the form of a complex obtained by the addition of protamine sulphate or another suitable protamine.

British Pharmacoepia and United States Pharmacopia definitions: [7]

Isophane Insulin

Sterile buffered suspension of insulin in the form of a complex obtained by addition of suitable protamine. Prepared from crystalline insulin. pH 6.9 - 7.5 iso-osmotic with blood. Contains for each 100 units of insulin, 300 - 600 g protamine sulphate and not more than 40 g zinc, a suitable bactericide and sodium phosphate as buffering agent.

USP specification: Sterile suspension of zinc insulin crystalline and protamine sulphate in buffered water for injection. Solid phase contain crystals of insulin protamine and zinc; 40, 80, 100 units/ml. Contains glycerol, metacresol, phenol sodium phosphate and zinc.

NPH/isophane insulinsEdit

The following commercial insulins are all generically NPH insulins:

Other commonly used names are:

  • NPH insulin, NPH
  • isophane insulin


Related pages
Lilly human insulins1992charts
Cp wockhardt bovine insulins
Iletin NPH
Hypurin Bovine Isophane