Betasint Bovine NPH | |
---|---|
NPH/isophane by Beta Laboratorios | |
intermediate-acting | |
Bovine | |
U40, U80, U100 | isophane |
Action in dogs:
| |
Line: Betasint | |
Also known as: Beef NPH, beef isophane | |
Similar to: Hypurin Bovine Isophane, Iletin NPH | |
Use and Handling: | |
Shelf Life: 36 months | Type: cloudy |
When Opened: 28 days room temp. | |
In Pen: 28 days room temp. | |
Notes: Protect from light and heat Do Not Freeze, Re-suspend Do not use if product does not re-suspend Cartridges in use are not to be refrigerated |
This is an intermediate-acting beef isophane insulin. Betasint Bovine NPH [2][3] is comparable to Hypurin Bovine Isophane. [4][5][6]
A comparable product, formerly made by Eli Lilly was all-beef Iletin I NPH.
Specifications of NPH/isophane insulin[]
British National Formulary [7] defines this type as: A sterile suspension bovine or porcine or of human insulin in the form of a complex obtained by the addition of protamine sulphate or another suitable protamine.
British Pharmacoepia and United States Pharmacopia definitions: [7]
Isophane Insulin
Sterile buffered suspension of insulin in the form of a complex obtained by addition of suitable protamine. Prepared from crystalline insulin. pH 6.9 - 7.5 iso-osmotic with blood. Contains for each 100 units of insulin, 300 - 600 g protamine sulphate and not more than 40 g zinc, a suitable bactericide and sodium phosphate as buffering agent.
USP specification: Sterile suspension of zinc insulin crystalline and protamine sulphate in buffered water for injection. Solid phase contain crystals of insulin protamine and zinc; 40, 80, 100 units/ml. Contains glycerol, metacresol, phenol sodium phosphate and zinc.
NPH/isophane insulins[]
The following commercial insulins are all generically NPH insulins:
NPH/Isophane Insulins | |
---|---|
All Intermediate acting | |
Betasint Bovine NPH Hypurin Bovine Isophane [4][8][6] | |
Iletin NPH
(No longer produced.) | |
Iletin I NPH
(No longer produced.) | |
Betasint Porcine NPH Hypurin Porcine Isophane [9][10] Hypurin Pork NPH | |
Iletin II NPH (No longer produced.) Pork Insulatard [9][11][12] (No longer produced.) Leo Retard (No longer produced.) | |
Huminsulin Basal, Humulin I Humulin N, Humulin NPH Humulina NPH, Humuline N Humuline NPH, Umuline NPH Humulin ReliOn N | |
Insuhuman Basal, Insuman Basal Isuhuman Basal, Winthrop Basal | |
Insulatard, Novolin N Protaphan, Protaphane | |
ReliOn/Novolin NPH (No longer produced) |
Other commonly used names are:
- NPH insulin, NPH
- isophane insulin
References[]
- ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ Betasint Bovine NPH. Beta Laboratorios.
- ↑ Google translation of Betasint Bovine NPH page.
- ↑ 4.0 4.1 Hypurin Bovine Isophane Patient Information. Net Doctor UK.
- ↑ Hypurin Bovine Isophane. Wockhardt UK.
- ↑ 6.0 6.1 Prescribing Bovine Insulin.
- ↑ 7.0 7.1 British National Formulary-Isophane/NPH Insulin Definition. InChem. Cite error: Invalid
<ref>
tag; name "InChem" defined multiple times with different content - ↑ Hypurin Bovine Isophane. Electronic Medicines Compendium UK.
- ↑ 9.0 9.1 Response to Withdrawal of Novo Porcine Insulins. CP/Wockhardt UK.
- ↑ Prescribing Porcine Insulin.
- ↑ Prescribing Novo Animal Insulin.
- ↑ Patient Information Leaflet-Pork Insulatard. Novo Nordisk.