| Betasint Porcine Corriente | |
|---|---|
| R, Neutral by Beta Laboratorios | |
| short-acting | |
| Porcine | |
| U40, U80, U100 | none |
Action in dogs:
| |
| Line: Betasint | |
| Also known as: Pork R, pork neutral | |
| Similar to: Hypurin Porcine Neutral Hypurin Pork Regular, Maxirapid CHO, Iletin II R Leo Neutral,[1] Pork Actrapid | |
| Use and Handling: | |
| Shelf Life: 36 months | Type: soluble, clear |
| When Opened: 6 weeks room temp. | |
| In Pen: 6 weeks room temp. | |
| Notes: Protect from light and heat Do Not Freeze, Cartridges in use are not to be refrigerated May be used intravenously May be used intramuscularly | |
Betasint logo. Bovine insulin was successfully extracted in January 1987-porcine followed in June of the same year.
Betasint Porcine Corriente [2][3] is a pork-based, short-acting insulin made by Beta Laboratorios. Maxirapid CHO is similar, as is CP Pharma's [4] Hypurin Porcine Neutral/Hypurin Pork Regular.
Eli Lilly's Iletin II R [5] was comparable, as was Novo Nordisk's Pork Actrapid. [6][7][8][9]which was discontinued at the end of December 2007[10]
As with all R/neutral insulins, regardless of species, nothing has been added to alter the speed or action of the insulin. [11][12]
A short-acting, soluble, non-suspended insulin produced from r-DNA/GE/GM, bovine, or porcine sources. From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.
While both R/neutral and semilente insulins are considered fast-acting, they differ in a few ways. As above, there's no suspension or buffer [13] in R/neutral; it's totally dissolved and soluble, meaning it can safely be used intravenously. [14] The very small insulin particles in semilente insulin are suspended by zinc. [13] Semilente is cloudy, has an acetate buffer and cannot be used intravenously.
R/Neutral insulin cannot be reliably mixed with Lente or Ultralente insulins. [15][16] Semilente can; the ratio of 3 parts semilente insulin to 7 parts ultralente insulin produces Lente insulin. [13]
R/Neutral Insulins[]
|
R/Neutral Insulins | |
|---|---|
|
All Short acting |
| Hypurin Bovine Neutral Betasint Bovine Corriente | |
| Hypurin Vet Neutral (No longer produced.) Iletin R (No longer produced.) Insuvet Neutral (No longer produced.) | |
| Iletin I R (No longer produced.) Leo Neutral (No longer produced.) | |
| Hypurin Porcine Neutral Hypurin Pork Regular Betasint Porcine Corriente, Maxirapid CHO | |
| Pork Actrapid (No longer produced.) Iletin II R (No longer produced.) | |
| Actrapid, Huminsulin Normal Humulin C, Humulin R Humulin Regular, Humulina Regular Humuline R, Humuline Regular Humulin S, Insuman Rapid Novolin R, Umuline Rapide Umuline Regular, Winthrop Rapid Humulin ReliOn R | |
| R-DNA | ReliOn/Novolin R (No longer produced.) |
References[]
- ↑ Montgomery, DAD. Modern Insulin and Insulin Therapy. Royal Victoria Hospital-Belfast.
- ↑ Betasint Porcine Corriente.
- ↑ Google Translation of Betasint Porcine Corriente page.
- ↑ Hypurin Porcine Neutral. Wockhardt UK.
- ↑ US-FDA Iletin II R Discontinuation Notice. Eli Lilly (July 2005).
- ↑ Pork Actrapid Patient Information. Net Doctor UK.
- ↑ Patient Information Leaflet-Pork Actrapid. Novo Nordisk.
- ↑ Prescribing Porcine Insulin.
- ↑ Prescribing Novo Animal Insulin.
- ↑ Pork Actrapid Discontinuation Notice. Wockhardt UK.
- ↑ Hypurin Porcine Neutral Patient Information. Wockhardt UK.
- ↑ Humulin R. Eli Lilly.
- ↑ 13.0 13.1 13.2 DeRuiter, Jack. Insulin Preparations-Regular Insulin. Auburn University. Cite error: Invalid
<ref>tag; name "Auburn" defined multiple times with different content Cite error: Invalid<ref>tag; name "Auburn" defined multiple times with different content - ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ Deckert, T. (1980). Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente. Diabetes Care.
Note--in 1980, there were no r-DNA/GE/GM insulins - ↑ Resource Guide. American Diabetes Association (2005).
More Information[]
- NACDS-Insulin Chart-Page 2
- Insulin therapy for dogs and cats Dowling, Patricia, September 1995, Canadian Veterinary Journal
A discussion of Iletin insulins.
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