Ketostix measure urine ketones.
Ketodiastix measure both urine glucose and urine ketones.
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Because most urine tests measure acetoacetic acid, and not the most commonly found beta-hydroxybutyrate acid, it is possible to have ketones present and get a negative urine test result. Further, it's also possible to have high levels of beta-hydroxybutyrate acid, get a negative urine ketone test result, but to have the test turn positive as the ketosis improves, due to the tests' measuring acetoacetic acid and not beta-hydroxybutyrate acid. [1] | ||
The following medications and/or problems with urine samples can produce false negative or false postive results when testing urine for ketones.
See Urine testing stix-Reading Results for examples of ketodiastix and ketostix color charts.
|
Possible False Urine Ketone Test Results--Drugs and Supplements | |
|---|---|
| Valproic Acid (brand names) Depakene, Depakote, Divalproex Sodium [2] |
Positive. Common use: Treatment of epilepsy. |
| Cefixime/Suprax [3] | Positive with nitroprusside-based urine testing. Common use: Antibiotic. |
| Levadopa Metabolites [4] | Positive with high concentrations [5][6]. |
| Tricyclic Ring Compounds [7][8] | Positive. Common use: Treatment of depression. |
| Captopril- other drugs with free sulfhydryl groups [7] |
Positive. Captopril Common use: Hypertension (high blood pressure), various heart conditions, preserving kidney function in diabetic nephropathy [9][6]. |
| Phenazopyridine Pyridium, Geridium, Pyridiate, or Urogesic [10][11]. |
Positive. Common use: Urinary tract infections. |
| Glucocorticoids/Steroids [12] | Positive. Common use: Allergies, replacement therapy, others. |
| Vitamin C Supplements [13][6][14]. | Negative. |
|
Possible False Urine Ketone Test Results-Other Reasons | |
|---|---|
| Pigmented Urine [5] | Positive- Any other color except yellow or clear [15] May be the result of other disease processes. |
| Dehydration [10][16] | Positive or negative lack of fluids can concentrate ketones |
| samples with high specific gravity and low pH [17] |
Positive. |
| Old Urine Sample [5] | Negative- ketones can evaporate rapidly.[18]
|
| Older opened test strip container [19][14] | Negative |
If your pet is taking any type of vitamin supplements, it should be noted on his or her medical records. Knowing that he/she is using them means being able to factor them into interpretations of test results.
References[]
- ↑ Patient.co.uk-Ketones-False Positives, False Negatives. Patient.co.uk.
- ↑ Valproic Acid. NetDoctor UK.
- ↑ Suprax/Cefixime. RXList.com.
- ↑ Levadopa. Drugs.com.
- ↑ 5.0 5.1 5.2 Sine, Cheryl S, et. al. (2003). Urinalysis Dipstick Interpretations-Ketones. University of Georgia. Cite error: Invalid
<ref>tag; name "Sine" defined multiple times with different content Cite error: Invalid<ref>tag; name "Sine" defined multiple times with different content - ↑ 6.0 6.1 6.2 Hanas, Ragnar. Measuring Ketones in Blood. Children With Diabetes.
- ↑ 7.0 7.1 Taylor, Judith A. (November 2006). Clinical Lab Medicine Harvesting The Gold: Interpretation and Techniques of Urinalysis. District of Columbia Academy of Veterinary Medicine.
- ↑ Tricyclic Antidepressant. Wikipedia.
- ↑ Captopril. Wikipedia.
- ↑ 10.0 10.1 Ketone Test Explained. Diabetes Explained. Cite error: Invalid
<ref>tag; name "Explained" defined multiple times with different content - ↑ Phenazopyridine. Merck Manuals Online.
- ↑ Ketones. Medline Plus.
- ↑ Precision Xtra Blood Ketone Test Strips. Abbott Diabetes Care.
- ↑ 14.0 14.1 Hanas, Ragnar. Measuring Ketones in Urine. Children With Diabetes.
- ↑ Taylor, Judith A. (November 2006). Urinalysis: What Is Abnormal?. District of Columbia Academy-Veterinary Medicine.
- ↑ Dehydration and Ketosis. North American Veterinary Conference (2003).
- ↑ Preanalytical Variables in Urine Testing. BD Diabetes (2006).
- ↑ Consequences of inappropriate urine specimen storage. Chronolab.
- ↑ Precision Xtra-When is it Recommended to Test?. Abbott Diabetes Care.
More Information[]
- Urine Ketones Cornell University