| Humulin I | |
|---|---|
| NPH/Isophane by Eli Lilly | |
| intermediate-acting | |
| r-DNA/GE/GM | |
| U40, U100 | isophane |
| Action in dogs: | |
| Line: Humulin | |
| Also known as: Humulin N, Huminsulin Basal, Humulin NPH, Humulina NPH, Humuline N, Humuline NPH, Umuline NPH Humulin ReliOn N | |
| Similar to: Novolin N, Insulatard, Protaphan Insuhuman Basal, Protaphane, Winthrop Basal ReliOn/Novolin NPH, Insuman Basal Isuhuman Basal Names of Lilly r-DNA/GE/GM insulins worldwide | |
| Use and Handling: | |
| Shelf Life: 24 months | Type: cloudy |
| When Opened: 28 days room temp. | |
| In Pen: 28 days room temp. | |
| Notes: Protect from light and heat Do Not Freeze, Resuspend Do not use if product does not re-suspend Do not use intravenously [3] | |
Humulin I-an intermediate-acting NPH/Isophane insulin. Note the similar packaging for comparable insulin Insuman Basal.
This is the Euro name for Lilly's isophane-suspension insulin [4]--the "I" an abbreviation for isophane. [5][6]
Lilly makes the same insulin known as Humulin N, [7] in North America [8] Humulina NPH, Umuline NPH, Humuline NPH, and Huminsulin Basal.
Like all other isophane/protamine suspended insulins, it is a crystalline suspension with protamine.
This type of insulin tends to have an onset of 2-4 hours, a peak action of 4-10 hours, and a total duration of 10-20 hours, in humans.
Novo Nordisk also has their Novolin N, [9] Protaphane and Insulatard [10][11][12][13] while Aventis has their Insuman Basal [14][15] and Winthrop Basal.
Specifications of NPH/isophane insulin[]
British National Formulary [16] defines this type as: A sterile suspension bovine or porcine or of human insulin in the form of a complex obtained by the addition of protamine sulphate or another suitable protamine.
British Pharmacoepia and United States Pharmacopia definitions: [16]
Isophane Insulin
Sterile buffered suspension of insulin in the form of a complex obtained by addition of suitable protamine. Prepared from crystalline insulin. pH 6.9 - 7.5 iso-osmotic with blood. Contains for each 100 units of insulin, 300 - 600 g protamine sulphate and not more than 40 g zinc, a suitable bactericide and sodium phosphate as buffering agent.
USP specification: Sterile suspension of zinc insulin crystalline and protamine sulphate in buffered water for injection. Solid phase contain crystals of insulin protamine and zinc; 40, 80, 100 units/ml. Contains glycerol, metacresol, phenol sodium phosphate and zinc.
NPH/isophane insulins[]
The following commercial insulins are all generically NPH insulins:
|
NPH/Isophane Insulins | |
|---|---|
|
All Intermediate acting |
| Betasint Bovine NPH Hypurin Bovine Isophane [17][18][19] | |
| Iletin NPH
(No longer produced.) | |
| Iletin I NPH
(No longer produced.) | |
| Betasint Porcine NPH Hypurin Porcine Isophane [20][21] Hypurin Pork NPH | |
| Iletin II NPH (No longer produced.) Pork Insulatard [20][22][23] (No longer produced.) Leo Retard (No longer produced.) | |
| Huminsulin Basal, Humulin I Humulin N, Humulin NPH Humulina NPH, Humuline N Humuline NPH, Umuline NPH Humulin ReliOn N | |
| Insuhuman Basal, Insuman Basal Isuhuman Basal, Winthrop Basal | |
| Insulatard, Novolin N Protaphan, Protaphane | |
| ReliOn/Novolin NPH (No longer produced) | |
Other commonly used names are:
- NPH insulin, NPH
- isophane insulin
References[]
- ↑ Insulins. North American Veterinary Conference (2005).
- ↑ Ruchinsky, Renee, et. al. (2010). Diabetes Management Guidelines for Dogs and Cats-page 7. American Animal Hospital Association.
- ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ Humulin I Prescribing Information.
- ↑ Patient Information Leaflet-Humulin I. Eli Lilly.
- ↑ Lilly UK Product Names & Time Activity Profiles. Eli Lilly.
- ↑ Humulin N-NPH/Isophane Human Insulin. Revolution Health.
- ↑ Humulin N patient leaflet. Eli Lilly.
- ↑ Novolin N. Revolution Health.
- ↑ Patient Information Leaflet-Insulatard. Novo Nordisk.
- ↑ Scientific Discussion-Insulatard. EMEA.
- ↑ Prescribing Novo Insulins.
- ↑ Scientific Discussion-Protaphane. EMEA.
- ↑ Patient Information Leaflet-Insuman Basal. Sanofi-Aventis.
- ↑ Insuman Prescribing Information.
- ↑ 16.0 16.1 British National Formulary-Isophane/NPH Insulin Definition. InChem. Cite error: Invalid
<ref>tag; name "InChem" defined multiple times with different content - ↑ Hypurin Bovine Isophane Patient Information. Net Doctor uk..
- ↑ Hypurin Bovine Isophane. Wockhardt UK.
- ↑ Prescribing Bovine Insulin.
- ↑ 20.0 20.1 Response to Withdrawal of Novo Porcine Insulins. CP/Wockhardt UK.
- ↑ Prescribing Porcine Insulin.
- ↑ Prescribing Novo Animal Insulin.
- ↑ Patient Information Leaflet-Pork Insulatard. Novo Nordisk.
More Information[]
- NACDS-Insulin Chart-Page 2
- Insulin therapy for dogs and cats Dowling, Patricia, September 1995, Canadian Veterinary Journal
A discussion of NPH/isophane insulins.
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