| Hypurin Bovine Isophane | |
|---|---|
| NPH/isophane by CP Pharma | |
| intermediate-acting | |
| Bovine | |
| U100 | isophane |
Action in dogs:
| |
| Line: Hypurin | |
| Also known as: Beef NPH, beef isophane | |
| Similar to: Betasint Bovine NPH, Iletin NPH | |
| Use and Handling: | |
| Shelf Life: 36 months | Type: cloudy |
| When Opened: 28 days room temp. | |
| In Pen: 28 days room temp. | |
| Notes: Protect from light and heat Do Not Freeze, Re-suspend Do not use if product does not re-suspend Cartridges in use are not to be refrigerated | |
Hypurin Bovine insulins-Hypurin Bovine Isophane is at right with a brown cap.
Hypurin Bovine Isophane is a beef-based intermediate-acting insulin made by CP Pharma. [2][3][4]
A comparable product,made by Beta Laboratorios is Betasint Bovine NPH; one formerly made by Eli Lilly was all-beef Iletin I NPH.
Specifications of NPH/isophane insulin[]
British National Formulary [5] defines this type as: A sterile suspension bovine or porcine or of human insulin in the form of a complex obtained by the addition of protamine sulphate or another suitable protamine.
British Pharmacoepia and United States Pharmacopia definitions: [5]
Isophane Insulin
Sterile buffered suspension of insulin in the form of a complex obtained by addition of suitable protamine. Prepared from crystalline insulin. pH 6.9 - 7.5 iso-osmotic with blood. Contains for each 100 units of insulin, 300 - 600 g protamine sulphate and not more than 40 g zinc, a suitable bactericide and sodium phosphate as buffering agent.
USP specification: Sterile suspension of zinc insulin crystalline and protamine sulphate in buffered water for injection. Solid phase contain crystals of insulin protamine and zinc; 40, 80, 100 units/ml. Contains glycerol, metacresol, phenol sodium phosphate and zinc.
NPH/isophane insulins[]
The following commercial insulins are all generically NPH insulins:
|
NPH/Isophane Insulins | |
|---|---|
|
All Intermediate acting |
| Betasint Bovine NPH Hypurin Bovine Isophane [2][3][4] | |
| Iletin NPH
(No longer produced.) | |
| Iletin I NPH
(No longer produced.) | |
| Betasint Porcine NPH Hypurin Porcine Isophane [6][7] Hypurin Pork NPH | |
| Iletin II NPH (No longer produced.) Pork Insulatard [6][8][9] (No longer produced.) Leo Retard (No longer produced.) | |
| Huminsulin Basal, Humulin I Humulin N, Humulin NPH Humulina NPH, Humuline N Humuline NPH, Umuline NPH Humulin ReliOn N | |
| Insuhuman Basal, Insuman Basal Isuhuman Basal, Winthrop Basal | |
| Insulatard, Novolin N Protaphan, Protaphane | |
| ReliOn/Novolin NPH (No longer produced) | |
Other commonly used names are:
- NPH insulin, NPH
- isophane insulin
References[]
- ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ 2.0 2.1 Hypurin Bovine Isophane Patient Information. Net Doctor.uk. Cite error: Invalid
<ref>tag; name "NetDoctor" defined multiple times with different content - ↑ 3.0 3.1 Hypurin Bovine Isophane. Wockhardt UK.
- ↑ 4.0 4.1 Prescribing Bovine Insulin.
- ↑ 5.0 5.1 British National Formulary-Isophane/NPH Insulin Definition. InChem. Cite error: Invalid
<ref>tag; name "InChem" defined multiple times with different content - ↑ 6.0 6.1 Response to Withdrawal of Novo Porcine Insulins. CP/Wockhardt UK.
- ↑ Prescribing Porcine Insulin.
- ↑ Prescribing Novo Animal Insulin.
- ↑ Patient Information Leaflet-Pork Insulatard. Novo Nordisk.
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