Fandom

Canine Diabetes Wiki

Apidra

Redirected from Glulisine

349pages on
this wiki
Add New Page
Talk2 Share

Apidra is a brand name for insulin glulisine, [1] a fast-acting human analog manufactured by Aventis. It is a soluble insulin and can be used intravenously for diabetic emergencies such as DKA. Apidra has been found to be equipotent (equally potent) to R/neutral R-DNA/GE/GM insulin when administered intravenously.

Given subcutaneously in normal injection form, Apidra has a more rapid onset and shorter duration than R human insulin. [2]


Technical detailsEdit

Insulin hex di mon

Insulin hexamers must break down into dimers and monomers to be absorbed. [3].

CP120

Alterations in the human insulin chains to produce Apidra (Glulisine), Novolog/NovoRapid (Aspart), and Humalog (Lispro)--all rapid-acting analog insulins.


The alterations to the human insulin molecule that produces insulin Glulisine are all to the B insulin chain; position B-#3, which is normally amino acid asparagine is replaced with lysine and the lysine amino acid which is normally found at position B-#29 is replaced by glutamic acid. [4]. Making substitutions at these positions on the B insulin chain, inhibits hexamer formation [5]

Since insulin in hexamer form must break down into dimers and monomers to become active, inhibiting the molecule's natural tendency to form hexamers by self-association, means better, faster absorption, more rapid onset, peak and shorter duration. Apidra [6] may be diluted for all uses except in insulin pumps. It may be mixed in the same syringe with NPH/isophane insulin only.

There is no clinical data regarding same syringe mixing of Apidra and any other insulin preparations in humans, but testing conducted in dogs indicates a slower onset when mixed with NPH/isophane insulin. Used on its own, Apidra displayed an earlier onset with them. [5] Antibody formation in the dog was noted.

Dr. Nelson of University of California-Davis said in his lecture at the Ohio State Endocrinology Symposium in 2006 that if the short-acting analog insulins have any role in feline and canine diabetes, it is not yet determined. [7]


Analog Insulins: amino acid sequencesEdit

Analog Insulins: pharmacokineticsEdit


These are human activity profiles.

ReferencesEdit

  1. Insulin glulisine-Apidra. Revolution Health.
  2. Patient Information-Apidra. RxList.com.
  3. Hanas, Ragnar (1999). Insulin Dependent Diabetes-Page 5. ChildrenWithDiabetes.
  4. Prescribing Information-Apidra. Sanofi-Aventis.
  5. 5.0 5.1 Scientific Discussion-Insulin Glulisine-Apidra-Page 1. EMEA.
  6. Apidra Information. Sanofi-Aventis.
  7. Nelson, Richard (2006). Selecting an Insulin for Treating Diabetes Mellitus in Dogs & Cats-Page 39. OSU Endocrinology Symposium.
  8. 8.0 8.1 Guide to Insulin Preparations. Pharmacy Times.
  9. 9.0 9.1 Insulin Pharmacology. Endotext.org.
  10. Hypurin Protamine Zinc. NetDoctor UK.

Ad blocker interference detected!


Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers

Wikia is not accessible if you’ve made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.