| Humulin 80/20 | |
| R/Neutral/NPH/Isophane Mix by Eli Lilly | |
| intermediate-acting | r-DNA/GE/GM |
| U100 | isophane |
| Line | Eli Lilly |
| Also known as | Huminsulin Profil II, Humulin 20/80, Humulin M, Humulin M2, Humulina 20/80, Humuline 20/80, Profil 20, Profil II, Umuline Profil 20 |
| Similar to | |
| Action in dogs |
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| Use and Handling | |
|---|---|
| Type | cloudy |
| Shelf Life | 30 months |
| When opened | 6 weeks room temp. |
| In pen | 6 weeks room temp. |
| Notes |
|
Time activity profile for 20/80 (80/20) insulin.
Eli Lilly's name [3] for its 20% R/neutral and 80% NPH/isophane crystal [4] insulin which is intermediate-acting.
Its UK counterpart, Humulin M2, was discontinued in the EU & UK in July 2004. [5][6] Lilly also discontinued its North American version of this insulin, Humulin 20/80. The insulin is also known as Umuline Profil 20, Huminsulin Profil II and Humulina 20/80.
Comparable insulins, all Novo-made: Mixtard 20, [7][8][9] Penmix 20 [1] and Actraphane 20/80.
Mixed insulins cover a wide range as they can be animal origin, r-DNA/GE/GM origin or analog insulins. The non-analog mixed insulins are made up of intermediate-acting NPH/isophane insulin and short-acting R/neutral. normal insulin. The analog mixes are made from intermediate-acting protamine-suspended analog insulin (suspended similar to NPH/isophane insulin) and fast-acting analog insulin. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.
For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin.
The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork Iletin and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion:
| Non-Analog Mixed Insulins | ||
|---|---|---|
|
All Intermediate-acting | |
| Insulin Is | Expressed As | Expressed As |
| 10% R/Neutral Insulin 90% NPH/Isophane Insulin |
90/10 | 10/90 |
| 20% R/Neutral Insulin 80% NPH/Isophane Insulin |
80/20 | 20/80 |
| 30% R/Neutral Insulin 80% NPH/Isophane Insulin |
70/30 | 30/70 |
| 40% R/Neutral Insulin 60% NPH/Isophane Insulin |
60/40 | 40/60 |
| 50% R/Neutral Insulin 50% NPH/Isophane Insulin |
50/50 | 50/50 |
References[]
- ↑ 1.0 1.1 Penmix 20. Medsafe NZ. Cite error: Invalid
<ref>tag; name "Penmix" defined multiple times with different content - ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ Humulin 20/80. Rxmed.com.
- ↑ Scientific Discussion Actraphane. EMEA.
- ↑ Withdrawal of Humulin M2. Pharma Journal (July 2004).
- ↑ Lilly EU/UK Product Sheet & Time Activity Profiles. Eli Lilly.
- ↑ Insulins & Mixtures. NHS.
- ↑ Scientific Discussion-Mixtard. EMEA.
- ↑ Prescribing Novo Insulins.
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