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Humulin 80/20
R/Neutral/NPH/Isophane Mix by Eli Lilly
intermediate-acting r-DNA/GE/GM
U100 isophane
Line Eli Lilly
Also known as Huminsulin Profil II, Humulin 20/80, Humulin M, Humulin M2, Humulina 20/80Humuline 20/80, Profil 20, Profil II, Umuline Profil 20


Names of Lilly r-DNA/GE/GM insulins worldwide

Similar to  
Action in dogs  
  • onset 0.5-3h,
  • peak 2-10h,
  • duration 4-24h
Use and Handling
Type cloudy
Shelf Life 30 months
When opened 6 weeks room temp.
In pen 6 weeks room temp.
Notes  
20 80

Time activity profile for 20/80 (80/20) insulin.


Eli Lilly's name [3] for its 20% R/neutral and 80% NPH/isophane crystal [4] insulin which is intermediate-acting.

Its UK counterpart, Humulin M2, was discontinued in the EU & UK in July 2004. [5][6] Lilly also discontinued its North American version of this insulin, Humulin 20/80. The insulin is also known as Umuline Profil 20, Huminsulin Profil II and Humulina 20/80.

Comparable insulins, all Novo-made: Mixtard 20, [7][8][9] Penmix 20 [1] and Actraphane 20/80.

Mixed insulins cover a wide range as they can be animal origin, r-DNA/GE/GM origin or analog insulins. The non-analog mixed insulins are made up of intermediate-acting NPH/isophane insulin and short-acting R/neutral. normal insulin. The analog mixes are made from intermediate-acting protamine-suspended analog insulin (suspended similar to NPH/isophane insulin) and fast-acting analog insulin. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.

For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin.

The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork Iletin and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion:


ReferencesEdit

  1. 1.0 1.1 Penmix 20. Medsafe NZ.
  2. Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
  3. Humulin 20/80. Rxmed.com.
  4. Scientific Discussion Actraphane. EMEA.
  5. Withdrawal of Humulin M2. Pharma Journal (July 2004).
  6. Lilly EU/UK Product Sheet & Time Activity Profiles. Eli Lilly.
  7. Insulins & Mixtures. NHS.
  8. Scientific Discussion-Mixtard. EMEA.
  9. Prescribing Novo Insulins.
Related pages
20 80
Penfill Mixtard 20 1
20 80
20 80
Penmix 20
Mixtard 20
Humulin 20/80
Humulin M2

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