Iletin II R
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| Iletin II R | |
|---|---|
| R, Neutral by Eli Lilly | |
| short-acting | |
| Porcine | |
| U100 | none |
Action in dogs:
| |
| Line: Iletin | |
| Also known as: Pork R, pork neutral | |
| Similar to: Betasint Porcine Corriente Hypurin Porcine Neutral, [1] Hypurin Pork Regular Maxirapid CHO, Pork Actrapid, Leo Neutral [2] | |
| Use and Handling: | |
| Shelf Life: 24 months | Type: soluble, clear |
| When Opened: 28 days room temp. | |
| In Pen: N/A | |
| Notes: Protect from light and heat Do Not Freeze, May be used intravenously May be used intramuscularly | |
Added by We hope
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Note that some countries have the brand name in U40 strength. | ||
North American brand name for Eli Lilly's now discontinued [3][4][5] 100% U100 porcine R/neutral, soluble insulin.
Like all R or neutral insulins, nothing is added (suspensions) to alter the insulin's action or speed. [6]
Novo Nordisk produced a similar Pork Actrapid, [7][8] but discontinued it at the end of December 2007. [9]
CP Pharma--Hypurin Porcine Neutral [10][11][12][13], Beta Laboratorios--Betasint Porcine Corriente and Polfa Tarchomin--Maxirapid CHO are now the only producers.
Added by We hope
A short-acting, soluble, non-suspended insulin produced from r-DNA/GE/GM, bovine, or porcine sources. From 1921 to the 1930's when PZI was developed, R was the only kind of insulin available.
While both R/neutral and semilente insulins are considered fast-acting, they differ in a few ways. As above, there's no suspension or buffer [15] in R/neutral; it's totally dissolved and soluble, meaning it can safely be used intravenously. [16]
The very small insulin particles in semilente insulin are suspended by zinc. [15]. Semilente is cloudy, has an acetate buffer and cannot be used intravenously
R/Neutral insulin cannot be reliably mixed with Lente or Ultralente insulins. [17][18] Semilente can; the ratio of 3 parts semilente insulin to 7 parts ultralente insulin produces Lente insulin. [15]
R/Neutral Insulins
Edit
|
R/Neutral Insulins | |
|---|---|
| All Short acting All soluble |
| Hypurin Bovine Neutral Betasint Bovine Corriente | |
| Iletin R (No longer produced.) Hypurin Vet Neutral (No longer produced.) Insuvet Neutral (No longer produced.) | |
| Iletin I R (No longer produced.) | |
| Hypurin Porcine Neutral Hypurin Pork Regular Betasint Porcine Corriente, Maxirapid CHO | |
| Pork Actrapid (No longer produced.) Iletin II R (No longer produced.) Leo Neutral (No longer produced.) | |
| Actrapid, Huminsulin Normal Humulin C, Humulin R Humulin Regular, Humulina Regular Humuline R, Humuline Regular Humulin S, Insuman Rapid Novolin R, Umuline Rapide Umuline Regular, Winthrop Rapid Humulin ReliOn R | |
| R-DNA | ReliOn/Novolin R (No longer produced.) |
ReferencesEdit
- ↑ Response to Withdrawal of Novo Porcine Insulin Range. CP/Wockhardt UK.
- ↑ Montgomery, DAD. Modern Insulin and Insulin Therapy. Royal Victoria Hospital-Belfast.
- ↑ Lilly Discontinues Iletin II R & Iletin II N. US Food and Drug Administration (July 2005).
- ↑ Iletin II R carton photo.
- ↑ Iletin II R Discontinuation Sheet. Eli Lilly.
- ↑ Humulin R patient information leaflet. Eli Lilly.
- ↑ Pork Actrapid Patient Information. Net Doctor uk.
- ↑ Patient Information Leaflet-Pork Actrapid. Novo Nordisk.
- ↑ Pork Actrapid Discontinuation Notice. Novo Nordisk.
- ↑ Hypurin Porcine Neutral. Wockhardt UK.
- ↑ Prescribing Porcine Insulin.
- ↑ Hypurin Porcine Neutral Patient Information. Net Doctor uk.
- ↑ Prescribing Novo Animal Insulin.
- ↑ Caninsulin-Product Information. Intervet.
- ↑ 15.0 15.1 15.2 DeRuiter, Jack. Insulin Preparations-Regular Insulin. Auburn University.
- ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ Deckert, T. (1980). Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente. Diabetes Care.
Note--in 1980, there were no r-DNA/GE/GM insulins - ↑ Resource Guide. American Diabetes Association (2005).
More InformationEdit
- Insulin therapy for dogs and cats Dowling, Patricia, September 1995, Canadian Veterinary Journal
A discussion of Iletin insulins. - Insulin pork regular
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