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Iletin I Semilente
Semilente by Eli Lilly
short-acting
Bovine 85% Porcine 15%
U100 Zinc
Action in dogs:
  • onset within 45 minutes,
  • peak 2-4h,
  • duration 4-6h
Line: Iletin
Also known as:
Similar to:
Use and Handling:
Shelf Life: 24 months Type: cloudy
When Opened: 28 days room temp.
In Pen: N/A
Notes: Protect from light and heat
Do Not Freeze,
Re-suspend
Do not use if product does not re-suspend
Do not use intravenously [1]
Do not mix with non Lente-type insulins
1975 Lilly JAMA ad

From left-insulins Semilente ("S"), Protamine Zinc ("P"), NPH/isophane ("N"), Regular/neutral/normal ("R"), Lente ("L"), and Ultralente ("U").

Lilly human insulins1992charts

Lilly insulin products-1992. This insulin is shown as Iletin I Lente.


Note that some countries have the brand name in U40 strength.

This 85% beef, 15% pork insulin was part of Lilly's line of insulins as recently as 1992. Semilente insulin[2] has an activity pattern similar to that of R/Neutral.

What Semilente Is NotEdit

No Lente-type insulin regardless of species can contain any NPH/isophane insulin [3] or any R/Neutral insulin. [4][5]

Both are chemically impossible: the phenol preservative present in NPH/isophane alters the action of Lente-type insulins, creating a mixture with an approximate action of R/Neutral. [6][7]

The zinc suspension of Lente-type insulin binds R/Neutral, causing the short-acting insulin to slow, losing its short-acting effect. [8][9]

Before the invention of VetPen, Lente-type insulins could not be dispensed in pen or cartridge form because the glass ball formerly used to mix the insulin in these devices shattered the Lente crystals.[10]

Combining Lente Family InsulinsEdit


Insulin manufacturers [11] indicate that R/neutral and semilente, Lente, ultralente insulins are able to be combined in the same syringe, but only just before injection. In pre-filled syringes, the zinc suspension of the Lente-type insulins binds the R/neutral, causing it to lose its short-acting effect. Various studies have documented this, and some doctors advise against using R/neutral in the same syringe with the Lente family of insulins. [5][12][13][14]

None of the Lente family of insulins (semilente, Lente, Ultralente) can be combined with [15] NPH/isophane insulins. The phenol preservatives present in NPH-type insulins alters the Lente-types to the point where they become a close approximation of R/neutral, with regard to action. [16][14]

Keeping the phenol preservatives in mind, all protamine-suspended insulin mixes would be "off limits" regarding same syringe mixing with any Lente-type insulins. [14]

Mixing semilente with either NPH/isophane or PZI will alter the semilente insulin because of the phenol preservatives present in either of them.


ReferencesEdit

  1. Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
  2. Dumitriu, Severian (2001). Polymeric Biomaterials, Revised and Expanded 1104. CRC Press.
  3. Combining Lente-type Insulins with Phenol-Preserved Insulins. National Federation for the Blind.
  4. Lente Zinc Suspension Causes Loss Of R/Neutral Short-Acting Effect. Endotext.org.
  5. 5.0 5.1 Huffman DM, Garber AJ. (1991). Availability of Soluble (R/Neutral) Insulin in Mixed Preparations With Crystalline (Lente) & Ultralente GE Insulin. Clinical Therapeutics.
  6. Lente-Type Insulins & NPH/Isophane Insulins-A Bad Combination. National Federation for the Blind.
  7. Havlik I, Galasko G, Alberts E, Furman KI, Seftel HC. (1988). Solubility Changes on Mixing Short- and Long-acting Insulin Preparations. South African Medical Journal.
  8. Deckert, T. (1980). Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente. Diabetes Care.
    Note--in 1980, there were no r-DNA/GE/GM insulins
  9. Resource Guide. American Diabetes Association (2005).
  10. Hanas, Ragnar (1999). Insulin-Dependent Diabetes-Page 10. ChildrenWithDiabetes.
  11. Insulin Producers vs Doctors Re:Combining R/Neutral & Lente-type Insulins. Endotext.org.
  12. Bilo HJ, Heine RJ, Sikkenk AC, van der Meer J, van der Veen EA. (1987). Absorption Kinetics & Action Profiles-Single Subcutaneous Administration of Human Soluble (R/Neutral) & Lente Insulin. Diabetes Care.
  13. Heine RJ, Sikkenk AC, Eizenga WH, van der Veen EA. (1983). Delayed Onset of Action of Soluble (R/Neutral) Insulin After Premixing With Lente Insulin Diabetes. Research & Clinical Practice.
  14. 14.0 14.1 14.2 Insulin Therapy-Mixing Precautions. RxEd.org.
  15. Phenol Preservatives & Lente-type Insulins--A Bad Combination. National Federation for the Blind.
  16. Lente-Type Insulins & NPH/Isophane Insulins-A Bad Combination. National Federation for the Blind.

More informationEdit

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