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Insulinum semilente CHO

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Insulinum Semilente CHO
Semilente by Polfa Tarchomin
short-acting
Porcine
U80 Zinc
Action in dogs:
  • onset within 45 minutes,
  • peak 2-4h,
  • duration 4-6h
Line:
Also known as: pork semilente, semilente pork
Similar to: Novo Semilente MC, Semitard [1]
Use and Handling:
Shelf Life: 36 months Type: cloudy
When Opened: 6 weeks room temp.
In Pen: N/A
Notes: Protect from light and heat
Do Not Freeze,
Re-suspend
Do not use if product does not re-suspend
Do not use intravenously [2]
Do not mix with non Lente-type insulins
Lente insuline

Novo Nordisk Semilente MC 40- Porcine (Pork) Insulin-German Packaging. This is semilente pork insulin (Insulin vom Schwein) in U40 strength. Novo discontinued this insulin; Polfa-Tarchomin's Insulinum semilente CHO is a U80 replacement for it.


This [3][4] is the last "plain" semilente insulin in production. Novo Nordisk distributed their Novo Semilente MC in Germany, but not in places like the US, Canada and the UK. Semilente insulin [5] has an activity pattern similar to that of R/Neutral.

When Novo discontinued this insulin, it was Polfa Tarchomin [6] who agreed to produce Insulinum semilente CHO as a replacement for it; if they hadn't, there would be no more "standalone" semilente insulins available.

What Semilente Is NotEdit

No Lente-type insulin regardless of species can contain any NPH/isophane insulin [7] or any R/Neutral insulin. [8][9]

Both are chemically impossible: the phenol preservative present in NPH/isophane alters the action of Lente-type insulins, creating a mixture with an approximate action of R/Neutral. [10]

The zinc suspension of Lente-type insulin binds R/Neutral, causing the short-acting insulin to slow, losing its short-acting effect. [11][12]

Before the invention of VetPen, Lente-type insulins could not be dispensed in pen or cartridge form because the glass ball formerly used to mix the insulin in these devices shattered the Lente crystals.[13]

Combining Lente Family InsulinsEdit

None of the Lente family of insulins (semilente, Lente, Ultralente) can be combined with [10] NPH/isophane insulins. The phenol preservatives present in NPH-type insulins alters the Lente-types to the point where they become a close approximation of R/neutral, with regard to action. [10][14]

Keeping the phenol preservatives in mind, all protamine-suspended insulin mixes would be "off limits" regarding same syringe mixing with any Lente-type insulins. [14]

Insulin manufacturers [15] indicate that R/neutral and semilente, Lente, ultralente insulins are able to be combined in the same syringe, but only just before injection. In pre-filled syringes, the zinc suspension of the Lente-type insulins binds the R/neutral, causing it to lose its short-acting effect. Various studies have documented this, and some doctors advise against using R/neutral in the same syringe with the Lente family of insulins. [9][16][17][14]

ReferencesEdit

  1. Montgomery, DAD. Modern Insulin and Insulin Therapy. Royal Victoria Hospital-Belfast.
  2. Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
  3. Insulinum semilente CHO. Diabetes news.de.
  4. Google Translated Page for Insulinum semilente CHO. Polfa Tarchomin.
  5. Dumitriu, Severian (2001). Polymeric Biomaterials, Revised and Expanded 1104. CRC Press.
  6. About Polfa Tarchomin. Polfa Tarchomin.
  7. Combining Lente-type Insulins with Phenol-Preserved Insulins. National Federation for the Blind.
  8. Lente Zinc Suspension Causes Loss Of R/Neutral Short-Acting Effect. Endotext.org.
  9. 9.0 9.1 Huffman DM, Garber AJ. (1991). Availability of Soluble (R/Neutral) Insulin in Mixed Preparations With Crystalline (Lente) & Ultralente GE Insulin. Clinical Therapeutics.
  10. 10.0 10.1 10.2 Lente-Type Insulins & NPH/Isophane Insulins-A Bad Combination. National Federation for the Blind.
  11. Deckert, T. (1980). Intermediate-Acting Insulin Preparations: NPH (Isophane) & Lente. Diabetes Care.
    Note--in 1980, there were no r-DNA/GE/GM insulins
  12. Resource Guide. American Diabetes Association (2005).
  13. Hanas, Ragnar (1999). Insulin-Dependent Diabetes-Page 10. ChildrenWithDiabetes.
  14. 14.0 14.1 14.2 Insulin Therapy-Mixing Precautions. RxEd.org.
  15. Insulin Producers vs Doctors Re:Combining R/Neutral & Lente-type Insulins. Endotext.org.
  16. Bilo HJ, Heine RJ, Sikkenk AC, van der Meer J, van der Veen EA. (1987). Absorption Kinetics & Action Profiles-Single Subcutaneous Administration of Human Soluble (R/Neutral) & Lente Insulin. Diabetes Care.
  17. Heine RJ, Sikkenk AC, Eizenga WH, van der Veen EA. (1983). Delayed Onset of Action of Soluble (R/Neutral) Insulin After Premixing With Lente Insulin Diabetes. Research & Clinical Practice.

More informationEdit

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