Insuman Basal | |
---|---|
NPH/Isophane by Aventis | |
intermediate-acting | |
r-DNA/GE/GM | |
U40, U100 | isophane |
Action in dogs: | |
Line: Insuman | |
Also known as: Insuhuman Basal, Isuhuman Basal, Winthrop Basal | |
Similar to: Humulin I, Huminsulin Basal, Humulin N, Humulin NPH, Humulina NPH, Humuline NPH, Humuline N, Umuline NPH, Humulin ReliOn 70/30 Insulatard, Novolin N, Protaphan, Protaphane ReliOn/Novolin NPH Names of Lilly r-DNA/GE/GM insulins worldwide | |
Use and Handling: | |
Shelf Life: 24 months | Type: cloudy |
When Opened: 4 weeks room temp. | |
In Pen: 4 weeks room temp. | |
Notes: Protect from light and heat Do Not Freeze, Resuspend Do not use if product does not re-suspend Do not use intravenously [3] |
Note that some countries have the brand name in U40 strength. |
This is Aventis' brand name for its NPH/isophane suspension insulin, [4][5][6][7] which is intermediate-acting.
Both Novo Nordisk and Eli Lilly produce similar insulins under the names Novolin N, [8] Insulatard, [9] Protaphane, [10] Humulin N[11][12], Umuline NPH, Humulina NPH,Humuline NPH, Huminsulin Basal and Humulin I. [13][14][15]
Like all other isophane/protamine suspended insulins, it is a crystalline suspension with protamine.
This type of insulin tends to have an onset of 2-4 hours, a peak action of 4-10 hours, and a total duration of 10-20 hours, in humans.
Specifications of NPH/isophane insulin[]
British National Formulary [16] defines this type as: A sterile suspension bovine or porcine or of human insulin in the form of a complex obtained by the addition of protamine sulphate or another suitable protamine.
British Pharmacoepia and United States Pharmacopia definitions: [17]
Isophane Insulin
Sterile buffered suspension of insulin in the form of a complex obtained by addition of suitable protamine. Prepared from crystalline insulin. pH 6.9 - 7.5 iso-osmotic with blood. Contains for each 100 units of insulin, 300 - 600 g protamine sulphate and not more than 40 g zinc, a suitable bactericide and sodium phosphate as buffering agent.
USP specification: Sterile suspension of zinc insulin crystalline and protamine sulphate in buffered water for injection. Solid phase contain crystals of insulin protamine and zinc; 40, 80, 100 units/ml. Contains glycerol, metacresol, phenol sodium phosphate and zinc.
NPH/isophane insulins[]
The following commercial insulins are all generically NPH insulins:
NPH/Isophane Insulins | |
---|---|
All Intermediate acting | |
Betasint Bovine NPH Hypurin Bovine Isophane [18][19][20] | |
Iletin NPH
(No longer produced.) | |
Iletin I NPH
(No longer produced.) | |
Betasint Porcine NPH Hypurin Porcine Isophane [21][22] Hypurin Pork NPH | |
Iletin II NPH (No longer produced.) Pork Insulatard [21][23][24] (No longer produced.) Leo Retard (No longer produced.) | |
Huminsulin Basal, Humulin I Humulin N, Humulin NPH Humulina NPH, Humuline N Humuline NPH, Umuline NPH Humulin ReliOn N | |
Insuhuman Basal, Insuman Basal Isuhuman Basal, Winthrop Basal | |
Insulatard, Novolin N Protaphan, Protaphane | |
ReliOn/Novolin NPH (No longer produced) |
Other commonly used names are:
- NPH insulin, NPH
- isophane insulin
References[]
- ↑ Insulins. North American Veterinary Conference (2005).
- ↑ Ruchinsky, Renee, et. al. (2010). Diabetes Management Guidelines for Dogs and Cats-page 7. American Animal Hospital Association.
- ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ Patient Information Leaflet-Insuman Basal. Sanofi-Aventis.
- ↑ Insuman Prescribing Information.
- ↑ Aventis Poster-Insuman & Lantus Insulins. Sanofi-Aventis.
- ↑ Scientific Discussion-Insuman. EMEA.
- ↑ Novolin N. Revolution Health.
- ↑ Scientific Discussion-Insulatard. EMEA.
- ↑ Scientific Discussion-Protaphane. EMEA.
- ↑ Humulin N patient leaflet. Eli Lilly.
- ↑ Humulin N NPH/Isophane Human Insulin. Revolution Health.
- ↑ Patient Information Leaflet-Humulin I. Eli Lilly.
- ↑ Humulin I Prescribing Information.
- ↑ Lilly EU/UK Product Sheet & Time Activity Profiles. Eli Lilly.
- ↑ British National Formulary-Isophane/NPH Insulin Definition. InChem.
- ↑ British Pharmacoepia (BP) & United States Pharmacoepia (USP)-Isophane/NPH Insulin Defined. InChem.
- ↑ Hypurin Bovine Isophane Patient Information. Net Doctor uk..
- ↑ Hypurin Bovine Isophane. Wockhardt UK.
- ↑ Prescribing Bovine Insulin.
- ↑ 21.0 21.1 Response to Withdrawal of Novo Porcine Insulins. CP/Wockhardt UK.
- ↑ Prescribing Porcine Insulin.
- ↑ Prescribing Novo Animal Insulin.
- ↑ Patient Information Leaflet-Pork Insulatard. Novo Nordisk.
More Information[]
- Chart of Insuman Insulin Range Yorkshire Diabetes
- NACDS-Insulin Chart-Page 2
- Insulin therapy for dogs and cats Dowling, Patricia, September 1995, Canadian Veterinary Journal
A discussion of NPH/isophane insulins.
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