| Penmix 20 [1] | |
|---|---|
| R/Neutral/NPH/Isophane Mix by Novo Nordisk | |
| intermediate-acting | |
| r-DNA/GE/GM | |
| U100 | isophane |
Action in dogs:
| |
| Line: Novo | |
| Also known as: Actraphane 20/80, [2] Mixtard 20 [3] | |
| Similar to: Huminsulin Profil II, Humulin 20/80, [4] Humulina 20/80, Humuline 20/80, Humulin M2 Profil II, Humulin M, Umuline Profil 20, Profil 20 Humulin 80/20 Names of Lilly r-DNA/GE/GM insulins worldwide | |
| Use and Handling: | |
| Shelf Life: 30 months | Type: cloudy |
| When Opened: 6 weeks room temp. | |
| In Pen: 6 weeks room temp. | |
| Notes: Protect from light and heat Do Not Freeze, Resuspend Do not use if product does not re-suspend Do not use intravenously [5] | |
Time activity profile for 20/80 (80/20) insulin.
A mixed, intermediate-acting insulin [6] made by Novo Nordisk containing 20% R/neutral insulin and 80% NPH/isophane insulin crystals. [3]
Comparable product is also made by Novo: Actraphane 20/80. [2]
Eli Lilly once produced a similar insulin in the EU & UK called Humulin M2; [7] it was discontinued in July 2004. [8] The North American version of this, Humulin 20/80, has also been discontinued. Elsewhere, Lilly calls this insulin Huminsulin Profil II, Umuline Profil 20, Humuline 20/80, Humulina 20/80, and in some places, as Humulin M.
Another comparable product by Novo, Mixtard 20, was discontinued December 31, 2007. [9][10]
Mixed insulins cover a wide range as they can be animal origin, r-DNA/GE/GM origin or analog insulins. The non-analog mixed insulins are made up of intermediate-acting NPH/isophane insulin and short-acting R/neutral. normal insulin. The analog mixes are made from intermediate-acting protamine-suspended analog insulin (suspended similar to NPH/isophane insulin) and fast-acting analog insulin. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.
For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin.
The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork Iletin and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion:
| Non-Analog Mixed Insulins | ||
|---|---|---|
|
All Intermediate-acting | |
| Insulin Is | Expressed As | Expressed As |
| 10% R/Neutral Insulin 90% NPH/Isophane Insulin |
90/10 | 10/90 |
| 20% R/Neutral Insulin 80% NPH/Isophane Insulin |
80/20 | 20/80 |
| 30% R/Neutral Insulin 80% NPH/Isophane Insulin |
70/30 | 30/70 |
| 40% R/Neutral Insulin 60% NPH/Isophane Insulin |
60/40 | 40/60 |
| 50% R/Neutral Insulin 50% NPH/Isophane Insulin |
50/50 | 50/50 |
References[]
- ↑ Penmix 20. Medsafe NZ.
- ↑ 2.0 2.1 Scientific Discussion-Actraphane. EMEA.
- ↑ 3.0 3.1 Scientific Discussion-Mixtard. EMEA.
- ↑ Humulin 20/80. RxMed.com.
- ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ Prescribing Novo Insulins.
- ↑ Lilly Product Sheet & Time Activity Profiles. Eli Lilly.
- ↑ Withdrawal of Humulin M2. Pharma Journal (July 2004).
- ↑ Insulin Discontinuations-UK. NHS.
- ↑ Chart of Discontinued Novo Human Insulins. Novo Nordisk.
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