FANDOM


Pork Mixtard 30
R/Neutral/NPH/Isophane Mix by Novo Nordisk
intermediate-acting
Porcine
U40, U100 isophane
Action in dogs:
  • onset within 2 h,
  • peak 4-12h,
  • duration up to 24h
Line: Novo
Also known as: Mixtard Pork 30, Mixtard 30 MC
Similar to: Hypurin Porcine 30/70 Mix [1]
Use and Handling:
Shelf Life: 36 months Type: cloudy
When Opened: 6 weeks room temp.
In Pen: 6 weeks room temp.
Notes: Protect from light and heat
Do Not Freeze,
Re-suspend
Do not use if product does not Re-suspend
Do not refrigerate in use cartridges
Do not use intravenously [2]
May be used intramuscularly, which would make onset, peak and duration times shorter.
Pork Mixtard

Pork Mixtard.


Note that some countries have the brand name in U40 strength.

Pork Mixtard 30 was the European brand name for Novo Nordisk's porcine insulin mix consisting of 30% porcine R/neutral insulin and 70% porcine NPH/isophane insulin. [3][4]

It is the same as Hypurin Porcine 30/70 Mix. [5][6][7][8]

Pork Mixtard 30 was discontinued in the UK by the end of December 2007[9][10][11][12][13] according to the Novo Nordisk Australasia Home Page, [14] it was discontinued there by December, 2006. Users now order CP Pharma's Hypurin Porcine 30/70 Mix. [15]

Why Lente doesn't equal 70/30Edit

Lente-70 30

Direct comparison of insulin activity profiles for Lente and 70/30 insulins. The early strong action from the non-suspended R/neutral/normal insulin is seen at the "bump" from hours 0-6.

Let's look at the differences in the two insulins. Lente is comprised of 70 % long-acting Ultralente insulin and 30% short-acting Semilente insulin. So proportions of a long-acting and short-acting insulin are being combined to produce a intermediate-acting insulin. Both Ultralente and Semilente insulin are suspended by adding zinc and the size of their respective insulin crystals. The largest insulin crystals are those of Ultralente, while Semilente contains the smallest, or microcrystals. Simply put, you're combining a long insulin and a short insulin to make an intermediate-acting one.[16]

70/30 insulin starts with 70% NPH/isophane insulin, an intermediate-acting insulin which is suspended by protamine. To that, 30% R/neutral/normal insulin, which is short-acting and soluble, meaning there is no suspension; nothing is added to this insulin to delay its action. In this case, you are taking an intermediate-acting insulin with a suspension and adding to it a short-acting one with no suspension to create an intermediate-acting insulin.

So we have an insulin (Lente), made up of a long-acting and short-acting insulin, both with zinc suspensions, and a mixed insulin (70/30), made from an intermediate-acting protamine suspended insulin and a short-acting one without any suspension. Because of these differences, the insulin action profile for these two insulins is going to be quite different, even though both insulins are classed as intermediate-acting.

Mixed insulins cover a wide range as they can be animal origin, r-DNA/GE/GM origin or analog insulins. The non-analog mixed insulins are made up of intermediate-acting NPH/isophane insulin and short-acting R/neutral. normal insulin. The analog mixes are made from intermediate-acting protamine-suspended analog insulin (suspended similar to NPH/isophane insulin) and fast-acting analog insulin. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.

For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin.

The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork Iletin and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion:


ReferencesEdit

  1. Response to Withdrawal of Novo Porcine Insulins. CP/Wockhardt UK.
  2. Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
  3. Pork Mixtard 30 Patient Information. Net Doctor.co.uk.
  4. Patient Information Leaflet-Pork Mixtard 30. Novo Nordisk.
  5. Hypurin Porcine 30/70 Mix. Wockhardt UK.
  6. Hypurin Porcine 30/70 Mix Patient Information. Net Doctor.co.uk.
  7. Prescribing Novo Animal Insulins.
  8. Prescribing Porcine Insulins.
  9. Novo Pork Insulin Discontinuation Information. Novo Nordisk.
  10. Insulin Discontinuations-UK. NHS.
  11. Novo Nordisk Discontinues Animal Insulins Worldwide. Forum Insulin Schweiz.
  12. Pork Insulin Discontinuation Notice. NovoNordisk UK.
  13. Novo Pork Insulin Discontinuations. NHS (2007).
  14. Novo Nordisk Australasia Home Page--Novo Pork Insulin Discontinuation. Novo Nordisk.
  15. Wockhardt/Hypurin Insulin Substitutes. NHS.
  16. Greco, Deborah (2010). Treating Diabetes Mellitus in Dogs and Cats. Western Veterinary Conference.
Related pages
Human Activity Profiles Various Insulins
Hypurin Porcine 30/70 Mix

Ad blocker interference detected!


Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers

Wikia is not accessible if you’ve made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.