Rapidtard
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| Rapidtard | |
|---|---|
| R/Neutral/NPH/Isophane Mix by Novo Nordisk | |
| intermediate-acting | |
| Bovine 75% Porcine 25% | |
| U40, U100 | Isophane |
Action in dogs:
| |
| Line: Novo | |
| Also known as: | |
| Similar to: | |
| Use and Handling: | |
| Shelf Life: 36 months | Type: cloudy |
| When Opened: 6 weeks room temp. | |
| In Pen: N/A | |
| Notes: Protect from light and heat Do Not Freeze, Re-suspend Do not use if product does not re-suspend Do not use intravenously [1] | |
|
Note that some countries have the brand name in U40 strength. | ||
Rapidtard was a 75% Bovine NPH/isophane and 25% Porcine R/neutral/normal mixed insulin made by Novo Nordisk. The name appears to signify the insulin was a combination of Pork Actrapid and Bovine Insulatard, or NPH/isophane insulin. [2]
Mixed insulins cover a wide range as they can be animal origin, r-DNA/GE/GM origin or analog insulins. They can also vary in the fraction (amount or percent) of the two types (R/neutral and NPH/isophane) of insulin used to make a non-analog mix, and in the percentage of fast/rapid-acting analog insulin and slower-acting protamine suspended analog insulin.
For some reason, those in the US choose to list the slower, NPH/isophane based insulin fraction first, such as Humulin or Novolin 70/30. The rest of the world gives the faster insulin top billing and the result is 30/70. Regardless of how this is written, it means that the insulin is made up of 70% NPH/isophane insulin and 30% R/neutral insulin.
The most common mixes are 70/30 (30/70) (non analog) or 75/25 (25/75) (analog). There are no currently-marketed mixes which combine insulins of different origins. Eli Lilly's form of beef/pork Iletin and Novo Nordisk's Lentard were discontinued some time ago. Here are the most common ones that could cause confusion:
| Non-Analog Mixed Insulins | ||
|---|---|---|
| All Intermediate-acting | ||
| Insulin Is | Expressed As | Expressed As |
| 10% R/Neutral Insulin 90% NPH/Isophane Insulin | 90/10 | 10/90 |
| 20% R/Neutral Insulin 80% NPH/Isophane Insulin | 80/20 | 20/80 |
| 30% R/Neutral Insulin 80% NPH/Isophane Insulin | 70/30 | 30/70 |
| 40% R/Neutral Insulin 60% NPH/Isophane Insulin | 60/40 | 40/60 |
| 50% R/Neutral Insulin 50% NPH/Isophane Insulin | 50/50 | 50/50 |
References
Edit
- ↑ Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
- ↑ Montgomery, DAD. Modern Insulin and Insulin Therapy. Royal Victoria Hospital-Belfast.