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ReliOn/Novolin NPH

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ReliOn/Novolin NPH
NPH/Isophane by Novo Nordisk
intermediate-acting
r-DNA/GE/GM
U40, U100 isophane
Action in dogs:
  • onset 0.5-3h,
  • peak 2-10h, [1]
  • duration 4-24h [2]
Line: Novolin
Also known as: Novolin N, Insulatard,
Protaphan,  Protaphane
Similar to: Humulin I, Huminsulin Basal, Humulin N, Humulin NPH, Humulina NPH, Humuline NPH, Humuline N, Umuline NPH, Humulin ReliOn N
Insuhuman Basal, Winthrop Basal
Insuman Basal, Isuhuman Basal

Names of Lilly r-DNA/GE/GM insulins worldwide
Use and Handling:
Shelf Life: 30 months Type: cloudy
When Opened: 6 weeks room temp.
In Pen: 6 weeks room temp.
Notes: Protect from light and heat
Do Not Freeze, Resuspend
Do not use if product does not re-suspend
Do not use intravenously [3]
N insulin

ReliOn Novolin NPH insulin.


An NPH/isophane crystal insulin. [4][5] As of October 2010, ReliOn brand insulin was no longer made by Novo Nordisk, who had been responsible for producing the ReliOn insulins since 2000. [6][7] The ReliOn insulins are still offered in the same types, R, NPH, and 70/30 mix, but they are produced by Eli Lilly and branded as Humulin/ReliOn insulins. [8][9][10] Novolin insulins have NOT been discontinued; these insulins are available as Novolin N, Novolin R, and Novolin 70/30. Only the ReliOn/Novolin branded insulins have been phased out.

This type of insulin tends to have an onset of 2-4 hours, a peak action of 4-10 hours, and a total duration of 10-20 hours, in humans.

It was a protamine suspension insulin, made by Novo Nordisk especially for Wal-Mart and Sam's Club. [11][12]

The only difference between the vials was the addition of the ReliOn name and the cheaper price. There was no quality difference between this insulin and Novolin N[13], Insulatard or Protaphane [14]

Other comparable insulins by other manufacturers are: Umuline NPH, Humuline NPH, Humulina NPH, Huminsulin Basal, Humulin N, [15][16] Humulin I, [17]--the "I" an abbreviation for isophane, [18][19] Insuman Basal, [20][21] and Winthrop Basal.

Specifications of NPH/isophane insulinEdit

British National Formulary [22] defines this type as: A sterile suspension bovine or porcine or of human insulin in the form of a complex obtained by the addition of protamine sulphate or another suitable protamine.

British Pharmacoepia and United States Pharmacopia definitions: [23]

Isophane Insulin

Sterile buffered suspension of insulin in the form of a complex obtained by addition of suitable protamine. Prepared from crystalline insulin. pH 6.9 - 7.5 iso-osmotic with blood. Contains for each 100 units of insulin, 300 - 600 g protamine sulphate and not more than 40 g zinc, a suitable bactericide and sodium phosphate as buffering agent.

USP specification: Sterile suspension of zinc insulin crystalline and protamine sulphate in buffered water for injection. Solid phase contain crystals of insulin protamine and zinc; 40, 80, 100 units/ml. Contains glycerol, metacresol, phenol sodium phosphate and zinc.

NPH/isophane insulinsEdit

The following commercial insulins are all generically NPH insulins:


Other commonly used names are:

  • NPH insulin, NPH
  • isophane insulin

ReferencesEdit

  1. Insulins. North American Veterinary Conference (2005).
  2. Ruchinsky, Renee, et. al. (2010). Diabetes Management Guidelines for Dogs and Cats-page 7. American Animal Hospital Association.
  3. Maddison, Jill E.,Page, Stephen W.,Church, David B. (2008). Small Animal Clinical Pharmacology. Saunders Ltd..
  4. Scientific Discussion-Insulatard. EMEA.
  5. Prescribing Novo Insulins.
  6. A Change to ReliOn Insulin. ReliOn.
  7. Low Cost Insulin Available through major retailer. Diabetes Health (1 December 2000).
  8. Wal-Mart Changes Insulin Partners. Wall Street Journal (22 June 2010).
  9. Wal-Mart Press Release (22 June 2010).
  10. ReliOn insulins. ReliOn.
  11. ReliOn/Novolin insulins.
  12. ReliOn/Novolin NPH.
  13. Novolin N. Revolution Health.
  14. Scientific Discussion-Protaphane. EMEA.
  15. Humulin N. Eli Lilly.
  16. Humulin N NPH/Isophane Insulin. Revolution Health.
  17. Humulin I Prescribing Information.
  18. Patient Information Leaflet-Humulin I. Eli Lilly.
  19. Lilly EU/UK Product Sheet & Time Activity Profiles. Eli Lilly.
  20. Patient Information Leaflet-Insuman Basal. Sanofi-Aventis.
  21. Insuman Prescribing Information.
  22. British National Formulary-Isophane/NPH Insulin Definition. InChem.
  23. British Pharmacoepia (BP) & United States Pharmacoepia (USP)-Isophane/NPH Insulin Defined. InChem.
  24. Hypurin Bovine Isophane Patient Information. Net Doctor.co.uk.
  25. Hypurin Bovine Isophane. Wockhardt UK.
  26. Prescribing Bovine Insulin.
  27. Response to Withdrawal of Novo Porcine Insulins. CP/Wockhardt UK.
  28. Prescribing Porcine Insulin.
  29. Response to Withdrawal of Novo Porcine Insulins. CP/Wockhardt UK.
  30. Prescribing Novo Animal Insulin.
  31. Patient Information Leaflet-Pork Insulatard. Novo Nordisk.


More InformationEdit

Related Pages
21938f Humulin n NVN34740 72167 5 DSC02817 Insulatard NPHtap
Humulin I
Humulin N
Novolin N
Insuman Basal
Insulatard
Humulin ReliOn N

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